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Cell Seeding of PTFE Vascular Grafts in Humans
Endothelial cells were seeded onto a PTFE material which was subsequently used for a vascular graft for humans. There were nine patients treated with the seeded material in the study performed by Doctors Peter Zilla, Roland Fasol, Manfred Deutsch, Teddy Fishlein, Erich Minar, Alfons Hammerle, Olga Krapicka, and Margrit Kadletz. [3] -
Fabrication of Scaffolds Using SFF Technology Demonstrated
Techniques for manufacturing three dimensional polymer solid free-form scaffold made from biodegradable polyester were developed. Furthermore methods were found for making the surfaces selectively adhesive. Developed at MIT by Park A, Wu B, and Griffith LG. [4] -
3D Printed Polymer Scaffold Used for Liver Tissue Research
3D printed polymer scaffolds with intricate channels were created to study the survival and function of liver cells in an attempt to overcome limitations of other scaffolds due to insufficient oxygen diffusion. The hope is to enable treatment of end stage liver disease. The researchers were S S Kim, H Utsunomiya, J A Koski, B M Wu, M J Cima, J Sohn, K Mukai, L G Griffith, and J P Vacanti of the Children's Hospital and Harvard Medical School, University of Chicago Hospitals, and MIT. [5] -
Transplantation of a Tissue-Engineered Pulmonary Artery
A scaffold composed of a polycaprolactone–polylactic acid copolymer reinforced with woven polyglycolic acid was used to engineer tissue for a pediatric patient. Performed by Toshiharu Shin'oka MD and Yasuharu Imai MD of Tokyo Women's Medical University and Yoshito Ikada PhD of Suzuka University of Medical Science. [6] -
Collagen Scaffolds With Predefined Internal Morphology Produced
The University of Oxford and UMIST developed a process for creating a SFF collagen scaffold with a predefined internal structure. Such a process allows the design and creation of optimized collagen scaffolds. The reseachers involved were E Sachlos, N Reis, C Ainsley, B Derby, and JT Czernuszka. [7] -
Bilayered Elastomeric Scaffold Created
A scaffold made from two layers was designed for tissue engineering of small-diameter vascular grafts. The outer layer provided mechanical strength because it was fibrous while the inside layer was porous. It was seeded with muscle-derived stem cells for laboratory study. The research was performed at the University of Pittsburg by Lorenzo Soletti, Yi Hong, Jianjun Guan, John J. Stankus, Mohammed S. El-Kurdi, William R. Wagner, and David A. Vorp. [8] -
Acellular Scaffold Used For Human Skeletal Muscle Formation
A scaffold composed of a naturally occurring extracellular matrix was used to treat 5 patients which muscle loss. Researchers at the University of Pittsburg who were involved were Brian M. Sicari, J. Peter Rubin, Christopher L. Dearth, Matthew T. Wolf, Fabrisia Ambrosio, Michael Boninger. Neill J. Turner, Douglas J. Weber, Tyler W. Simpson, Aaron Wyse, Elke H. P. Brown, Jenna L. Dziki, and Lee E. Fisher. [9]