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Epigentic
Was first proposed by Waddingtong and defined a branch of biology that studied the causal interactions between genes and their products. -
The 3 major epigenetic processes
DNA methylation, histone modifications and non-coding RNAS. -
DNA methylation
Was the first recognized and the most well-characterized epigenetic modification. -
MICRO RNAs
They are a major class of small non-coding RNAs with about 20-22 nucleotides wich can mediate post ranscriptional regulation of gene expression. -
Fetal Programming Hypothesis (FPH)
Relation between the quality of early life environment and future risk of disease in later life. We found two speakers. After more than 20-year long term research, it has now been accepted worlwide. -
Dr. Forsdahls Kurve
Discovered that infant mortality rate was positively associated with an increased risk of cardiovascular diseases (CVD) in middle age. -
Professor David Barker
Found an inverse relationship between birth weight and increased CVD mortality -
Evidence from human cohorts
DNA Methylation and MicroRNAs -
MicroRNAs with FPH
the fetal growth restriction (FGR), is a relatively copmmon, pleiotropic complication of pregnancy. It is not only associeted with significantly increased perinatal morbidity and mortality, and is also a major determinant of cardiovascular disease and glucose intolerance in adult life. -
DNA methylation with FPH
Gestation is the critical time window for maternal nutrition to affect the offspring. Early life nutrition can induce persisten DNA methylation. Both unde-rnutrtion and over-nutrition will bring about epigenetic modification during the early life, including the embryonic development and neonatal period. -
Evidence from Animal Experiments
DNA Methylation and MicroRNAs -
DNA Methylation and Animal Experiments
Maternal and Paternal Nutrion -
Maternal Nutrion
Low protein diet is associated with impairedfetal growth, the development of obesity, insulin resistence and diabetes in the offspring. -
Paternal Nutrion
The parental malnourished exposures cpuld also affect the phenotype of the offspring. Paternal lifestyle and particular nutrion factors can effect spermatogenesis at the level of germ and sertoli cell and the composition of seminal fluid. -
Paternal Nutrion
Paternal lifestyle and particular nutrion factors can effect spermatogenesis at the level of germ and sertoli cell and the composition of seminal fluid. -
MicroRNAs and Animal Experiments
Maternal and Parental Nutrion -
Maternal Nutrion
Maternal conumption of a high fat diet can induce glucose intolerant and insulin intolerant, obesity and the abnormal lipid metabolism in the early life. -
Developmental Plasticity and Reversibility
Its has evoled to provide the best chances of survival and reproductive success to the organism.
