Major Biotech Innovations

  • Robert Hooke coined 'cells' , Leeuwenhoek observed first microorganisms

    Robert Hooke coined 'cells' , Leeuwenhoek observed first microorganisms
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    Before DNA

  • Gregor mendel discovers simple inheritance laws

    Gregor mendel discovers simple inheritance laws
    predicting trait outcomes
  • Lois Pasteur discovers fermentation and Germ theory

    Lois Pasteur discovers fermentation and Germ theory
  • Johann Mieshcer discovered DNA is inheritable

    Johann Mieshcer discovered DNA is inheritable
  • Thomas Hunt Morgan discovered genes were on chromosomes

    Thomas Hunt Morgan discovered genes were on chromosomes
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    DNA science

  • Fred Griffith proved that genetic material can move from one bacteria to another

    Fred Griffith proved that genetic material can move from one bacteria to another
  • Alexander Fleming isolated penicillin from fungus

    Alexander Fleming isolated penicillin from fungus
  • Chargaff showed that adenine pairs with thymine and cytosine pairs with guanine

    Chargaff showed that adenine pairs with thymine and cytosine pairs with guanine
  • Beadle and Tatum "one gene, one enzyme"

    Beadle and Tatum "one gene, one enzyme"
  • Avery, McCarty, and McLeod DNA is hereditary

    Avery, McCarty, and McLeod DNA is hereditary
  • Hershey and Chase proved viruses replicated as DNA

    Hershey and Chase proved viruses replicated as DNA
  • Rosalind Franklin established DNA is double helix

    Rosalind Franklin established DNA is double helix
  • Watson and Crick discovered DNA structure

    Watson and Crick discovered DNA structure
  • Hayes discovered plasmid DNA

    Hayes discovered plasmid DNA
  • Walter GIlbert discovered gene expression through RNA

    Walter GIlbert discovered gene expression through RNA
  • Arber, Nathans, and Smith discovered enzymes that cut DNA

    Arber, Nathans, and Smith discovered enzymes that cut DNA
  • Khorana, and Nirenberg discovered 64 codons(3 bases of DNA)

    Khorana, and Nirenberg discovered 64 codons(3 bases of DNA)
  • DNA plasmids were isolated and purified by Vinograd

    DNA plasmids were isolated and purified by Vinograd
  • Madel and Higa first transformation of bacterium Escherichia coli.

    Madel and Higa first transformation of bacterium Escherichia coli.
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    Rcombinant DNA Tech

  • cloning experiments conducted by boyer and cohen

    cloning experiments conducted by boyer and cohen
  • genetech was founded

    genetech was founded
  • scientsts met to draw up guidelines for work with recombinant dna

    scientsts met to draw up guidelines  for work with recombinant dna
  • Sanger and Gilbert found a way to sequence DNA

    Sanger and Gilbert found a way to sequence DNA
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    New tools

  • boyer inserted a synthetic insulin gene into e.coli

    boyer inserted a synthetic insulin gene into e.coli
  • Botstein found that you can be identified by DNA

    Botstein found that you can be identified by DNA
  • Louise Joy Brown was born who was made in a petri dish

    Louise Joy Brown was born who was made in a petri dish
  • Ohio University scientists made trasgenic animals

    Ohio University scientists made trasgenic animals
  • The u.s supreme court ruled that genetically altered life forms can be patented

    The u.s supreme court ruled that genetically altered life forms can be patented
  • Eli Lilly Company placed insulin gene in bacteria

    Eli Lilly Company placed insulin gene in bacteria
  • Schell, Chilton , Van Mantagu transformed plants

    Schell, Chilton , Van Mantagu transformed plants
  • Kary Mullins invented PCR to amplify DNA

    Kary Mullins invented PCR to amplify DNA
  • Jeffries apllied RFLP in DNA profiling

    Jeffries apllied RFLP in DNA profiling
  • An automated fluorescence sequencer was invented

    An automated fluorescence sequencer was invented
  • Fenes were moved into an organism through gene gun

    Fenes were moved into an organism through gene gun
  • NIH revised safety guidelines

    NIH revised safety guidelines
  • Andrew Fire and Craig Mello discovered silencing of genes

    Andrew Fire and Craig Mello discovered silencing of genes
  • Kohler, Milstein, and Jerne used mab technology

    Kohler, Milstein, and Jerne used mab technology
  • Maynard Olson Invented expression vectors for proteins

    Maynard Olson Invented expression vectors for proteins
  • Ian Wilmut cloned Dolly the sheep

    Ian Wilmut cloned Dolly the sheep
  • Ability to look at genes on slide was developed

    Ability to look at genes on slide was developed
  • Dabiri and Garner made faster DNA sequencer

    Dabiri and Garner made faster DNA sequencer
  • Ron Breaker coined term riboswitch for mRNA

    Ron Breaker coined term riboswitch for mRNA
  • Completion of Human Genome Project

    Completion of Human Genome Project